Endocrine Abstracts

Background: TSH-suppressive therapy in patients with differentiated thyroid carcinoma (DTC) leads to iatrogenic thyrotoxicosis and may be associated with alterations in body composition and bone mineral density (BMD). Its effects on a sarcopenia in elderly have not been in detail investigated.Objective: The objective was to compare changes in total and areal lean body mass (LBM), body fat mass (BFM) and BMD in postmenopausal female patients with DTC duri...

BackgroundOnly limited data are available regarding adverse effects of gender affirming hormonal treatment (HT) mainly due to the lack of population-based studies with adequate controls, thus making spontaneous reporting systems a valuable tool to detect potential side reactions.ObjectiveIn this nationwide retrospective study, we aimed to analyse adverse drug reactions (ADRs) in relation to gender affirming H...

Background: During the last decennium, an increase in the number of persons referred to gender identity centres has been observed. Epidemiological data have not yet been formally studied in France. Here we report the experience from the Trans’Est Gender Identity Centre of the University Hospital of Nancy.Aim: To study the number of people seeking transgender care, the age at referral and the trends in the sex ratio.Methods: Th...

Folate and cobalamin are methyl donors (MD) needed for synthesis of methionine, precursor of S-adenosylmethionine (SAM), the substrate of methylation in epigenetic, and epigenomic pathways. The MD deficiency (MDD) leads to a decrease in SAM/SAH ratio and hyperhomocysteinemia, which has been related to osteoporosis in humans and disruption of development of epiphyseal cartilage in rat. However, the underlying molecular mechanisms remain elusive.M...

Background: In females transitioning to males (FtM) and in males transitioning to females (MtF), exogenous cross-sex steroids are prescribed to favour development of secondary characteristics of desired sex, while endogenous hormone production is inhibited.Aims and design: To study early impact of cross-sex steroids on body composition, metabolic profile and pro-inflammatory parameters in young transgender persons before and after 12 months of gender-aff...